Timeline (Mitopure) vs SOMA HEALTH: Urolithin A Compared

Timeline (the maker of Mitopure) and SOMA HEALTH both sell urolithin A, the same well-defined molecule at the center of the mitochondrial-health conversation. Because the active ingredient is identical in kind, a fair comparison comes down to dose, format, testing, value and the honest state of the science, not marketing. Here is a grounded walk through all of it.

Transparency note: SOMA HEALTH sells a urolithin A product, so we are a competitor to Timeline. We have kept this even-handed and focused on a framework you can apply to either brand.

What both products actually are

Urolithin A is a gut postbiotic. Your microbiome produces it from ellagitannins, the polyphenols concentrated in pomegranates, walnuts and some berries. The catch, and the reason a supplement exists at all, is that only some people carry the microbial makeup to convert those precursors into meaningful amounts of urolithin A. Eating pomegranates does not guarantee you make much of it. A direct urolithin A supplement sidesteps that conversion lottery by delivering the finished molecule.

Its most-studied role is supporting mitophagy, the cellular quality-control process that clears out worn, underperforming mitochondria so the cell can replace them with fresher ones. Healthier mitochondrial populations underpin how muscles and other tissues generate energy, which is why the human research has centered on muscle. Timeline pioneered and commercialized a branded form of urolithin A called Mitopure; SOMA HEALTH delivers urolithin A in a gummy. The molecule doing the work is the same category of compound. For the full background, see our urolithin A guide and mitochondrial health primer.

The evidence, labeled by strength

This is the part that should drive any purchase, and we cite only real studies, clearly separating human results from preclinical ones. Notably, much of the foundational human urolithin A research was conducted on the Mitopure form, which is a genuine point in Timeline's favor and worth acknowledging plainly.

Proven in humans

Andreux and colleagues (2019, Nature Metabolism) ran the first-in-human trial, finding urolithin A safe and well tolerated up to 1,000 mg per day and producing a measurable mitochondrial gene-expression signature. Liu, D'Amico and colleagues (2022, JAMA Network Open) studied older adults over roughly four months and reported improved muscle endurance, measured as the number of contractions before fatigue. Singh and colleagues (2022, Cell Reports Medicine) examined middle-aged adults across 500 mg and 1,000 mg arms over four months and observed benefits to muscle strength and exercise performance.

Newer human research

A 2025 Nature Aging randomized trial of about 28 days reported that urolithin A supported the mitochondrial health of immune cells in midlife adults, part of the emerging inflammaging picture. A 2024 trial in the Journal of the International Society of Sports Nutrition ran eight weeks in resistance-trained men and looked at endurance and recovery markers, and a 2025 trial studied distance runners. A 2024 systematic review in Ageing Research Reviews framed the field honestly: promising but still emerging, built on short trials with modest participant numbers.

Preclinical only (animal and cell)

Ryu and colleagues (2016, Nature Medicine) is the landmark preclinical study, showing urolithin A triggered mitophagy, extended lifespan in the worm C. elegans and improved muscle function in rodents. It is foundational but not human proof. D'Amico and colleagues (2022, Aging Cell) explored joint and cartilage mitochondrial health in osteoarthritis models. Applications to skin, gut, brain and heart remain early and preclinical. When you see those broader benefits advertised, treat them as areas early research is exploring, not established human outcomes. Our clinical studies page lays this out in full.

Dose: the number that matters most

The clinically studied range for urolithin A is 500 to 1,000 mg per day, with 1,000 mg at the top of that window. When comparing Timeline and SOMA HEALTH, the meaningful figure is milligrams in a full daily serving, not a per-capsule or per-scoop number in isolation. SOMA HEALTH is formulated to 1,000 mg per daily serving. Timeline sells Mitopure in several formats (softgels, powder and other options) at different strengths, so to compare fairly, read Timeline's current label for the exact milligrams per recommended daily serving and place it against the 500 to 1,000 mg range. Since Timeline's lineup and pricing change over time, check the current label rather than relying on a figure quoted secondhand. Our urolithin A dosage page explains why the full-serving total is the honest way to compare.

Format and adherence

The human trials that showed muscle benefits ran for roughly four months, which makes daily consistency a real variable in whether a product helps you. This is where format preference stops being trivial. Softgels and powders, which Timeline is known for, are familiar and flexible; powders can be stirred into food or drinks. A gummy, SOMA HEALTH's approach, removes pill-swallowing and measuring, which for many people translates into a more reliable daily habit. Neither format is superior in the abstract. The best one is whichever you will still be taking in month four. If you want the trade-offs in depth, see how to take urolithin A.

Testing, value and how to decide

Because urolithin A supplements are not tightly regulated before sale, third-party testing is the safeguard that the dose on the label is the dose in the product and that it has been screened for contaminants. SOMA HEALTH is third-party tested; Timeline likewise publicizes quality standards. For either brand, the actionable step is to confirm a current certificate of analysis is available for the product you are considering.

On value, normalize before you judge. Take the total price, divide by the number of daily servings to get cost per day, and if you want a true apples-to-apples figure, divide again by milligrams per serving. A product can look expensive per bottle yet be reasonable per milligram if each serving delivers a full 1,000 mg, and vice versa. Run that math on both brands using current prices.

The honest bottom line: Timeline has a strong claim as the brand behind much of the foundational human research on its form of urolithin A, and that history is a legitimate reason some people choose it. SOMA HEALTH competes on a full 1,000 mg daily dose in a sugar-free gummy that many find easier to stick with, third-party tested, at a transparent price. There is no universal winner. The right choice is the product whose dose lands in the studied range, whose testing you can verify, whose format you will take consistently, and whose per-milligram value fits your budget. Compare formats further in our best urolithin A gummies roundup.

Urolithin A is a dietary supplement that supports normal cellular and muscle function. It is not a treatment for any disease. If you have a medical condition, take medication, or are pregnant or nursing, talk with your doctor before starting any urolithin A product, and see your healthcare provider for anything involving a diagnosis.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This guide is educational and is not a substitute for advice from a qualified healthcare provider.