Codeage Liposomal Urolithin A Review

Reviewed by SOMA HEALTH's Medical Research Team

Codeage's Liposomal Urolithin A is a capsule that pairs urolithin A with a small stack of complementary longevity ingredients and leans on a “liposomal” delivery angle. This review breaks down the dose, what liposomal does and does not tell you, and how the formula lines up with the human evidence.

Full disclosure first: SOMA HEALTH makes its own urolithin A gummies, so we are a competitor to Codeage. To keep this fair, we stick to what the label states, label all animal and lab findings as preclinical, and avoid quoting Codeage's price. For anything time-sensitive, check the current label.

What is in the Codeage formula

Based on its listing, Codeage Liposomal Urolithin A provides 500 mg of urolithin A per serving, alongside trans-resveratrol, betaine anhydrous, and coenzyme Q10 (CoQ10), and it notes ellagitannins on the label. It is sold as 60 capsules and marketed as vegan and bioavailable. As with any multi-ingredient product, confirm the current per-serving amounts on the label before buying, since formulas change.

The most decision-relevant number is the 500 mg of urolithin A, which sits at the lower end of the range studied in people. The other ingredients — resveratrol, betaine, CoQ10 — are common in longevity blends and each carries its own separate evidence, but they are not urolithin A and were not part of the urolithin A trials.

What “liposomal” means here

Liposomal delivery wraps an ingredient in phospholipid spheres, and the theory is that this can improve how much of a compound is absorbed. It is a legitimate formulation approach used across the supplement world. The honest caveat is that a liposomal label is a claim about delivery, not a guarantee of a specific absorption result for urolithin A, and the pivotal human urolithin A trials did not use Codeage's particular liposomal preparation. So “liposomal” is worth noting, but it should not be read as making 500 mg equivalent to a higher studied dose. When you compare products, the amount of urolithin A per serving remains the clearest, most comparable number.

The human evidence, from strongest to newest

Urolithin A is a gut postbiotic your body makes from ellagitannins in pomegranate, walnuts, and berries — but only some microbiomes convert it efficiently, which is why standardized supplements exist. Its core mechanism is supporting mitophagy, the process of recycling worn-out mitochondria so cells can keep energy production clean and efficient.

Proven in humans

The first-in-human study (Andreux and colleagues, Nature Metabolism, 2019) found urolithin A safe and well tolerated up to 1,000 mg per day, with a measurable shift in a mitochondrial gene-expression signature. A four-month randomized trial in middle-aged adults (Singh and colleagues, Cell Reports Medicine, 2022) tested 500 mg and 1,000 mg per day and reported improvements in muscle strength and exercise performance. A separate four-month study in older adults (Liu, D'Amico and colleagues, JAMA Network Open, 2022) reported improved muscle endurance. These muscle- and mitochondria-focused results are the sturdiest human findings to date.

Newer human evidence

Recent trials extend the story. An eight-week randomized trial in resistance-trained men (Journal of the International Society of Sports Nutrition, 2024) looked at already-active people, and a 2025 trial studied distance runners. A 2025 randomized trial in Nature Aging (about 28 days) reported support for immune-cell mitochondrial health in midlife adults, relevant to “inflammaging.” The pattern is consistent: the human evidence at 500–1,000 mg per day is genuine but still emerging, as a 2024 systematic review in Ageing Research Reviews put it plainly.

Preclinical (animal and lab) research

Foundational work is preclinical. Ryu and colleagues (Nature Medicine, 2016) demonstrated mitophagy, extended lifespan in C. elegans, and improved muscle function in rodents. D'Amico and colleagues (Aging Cell, 2022) reported joint and cartilage benefits in osteoarthritis models. Skin, gut, brain, and heart applications remain in early, preclinical stages of research. Treat these as mechanism and hypothesis rather than proof in people.

Combination formula: convenience versus clarity

Codeage's approach is to bundle urolithin A with resveratrol, betaine, and CoQ10. If you were already planning to take those ingredients, one capsule is convenient. The trade-off is the same one that applies to any blend: when multiple actives share a capsule, each is usually present at a lower amount than in a dedicated single-ingredient product, and no ingredient is guaranteed to match its own clinical dose. If urolithin A is your priority, a single-ingredient product at 500–1,000 mg keeps the dosing transparent. Our urolithin A dosage guide and the main urolithin A guide walk through how to think about this.

Testing, format, and consistency

The things that matter most when comparing urolithin A products are the per-serving dose, evidence of quality testing, and whether you will take it every day. Capsules like Codeage's are compact and travel well; gummies suit people who dislike swallowing pills. Neither format is inherently superior — effectiveness tracks the daily amount of urolithin A and consistency, not the delivery shape. For a benefits-first comparison, see our urolithin A benefits overview.

Who it may suit, with a fair caveat

Codeage Liposomal Urolithin A may appeal to someone who wants urolithin A alongside resveratrol, betaine, and CoQ10 in one vegan capsule and is comfortable at 500 mg. Someone aiming for the 1,000 mg arm from the human trials, or who wants to know exactly how much of a single ingredient they are taking, may prefer a dedicated product. Remember that urolithin A is a structure/function supplement that supports mitochondrial and muscle health — it is not a treatment for any condition. If you are pregnant or nursing, managing a health issue, or taking medication, talk with your doctor before starting.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This guide is educational and is not a substitute for advice from a qualified healthcare provider.